|
KMID : 1044620220550050464
|
|
Journal of Preventive Medicine and Public Health
2022 Volume.55 No. 5 p.464 ~ p.474
|
|
|
The Korea Cohort Consortium: The Future of Pooling Cohort Studies
|
|
Lee Sang-Jun
Ko Kwang-Pil
Lee Jung-Eun
Kim In-Ah
Jee Sun-Ha
Shin Ae-Sun
Kweon Sun-Seog
Shin Min-Ho
Park Sang-Min
Ryu Seung-Ho
Yang Sun-Young
Choi Seung-Ho
Kim Jeong-Seon
Yi Sang-Wook
Kang Dae-Hee
Yoo Keun-Young
Park Sue-K.
|
|
|
Abstract
|
|
|
Objectives: We introduced the cohort studies included in the Korean Cohort Consortium (KCC), focusing on large-scale cohort studies established in Korea with a prolonged follow-up period. Moreover, we also provided projections of the follow-up and estimates of the sample size that would be necessary for big-data analyses based on pooling established cohort studies, including population-based genomic studies.
Methods: We mainly focused on the characteristics of individual cohort studies from the KCC. We developed “PROFAN”, a Shiny application for projecting the follow-up period to achieve a certain number of cases when pooling established cohort studies. As examples, we projected the follow-up periods for 5000 cases of gastric cancer, 2500 cases of prostate and breast cancer, and 500 cases of non-Hodgkin lymphoma. The sample sizes for sequencing-based analyses based on a 1:1 case-control study were also calculated.
Results: The KCC consisted of 8 individual cohort studies, of which 3 were community-based and 5 were health screening-based cohorts. The population-based cohort studies were mainly organized by Korean government agencies and research institutes. The projected follow-up period was at least 10 years to achieve 5000 cases based on a cohort of 0.5 million participants. The mean of the minimum to maximum sample sizes for performing sequencing analyses was 5917-72 102.
Conclusions: We propose an approach to establish a large-scale consortium based on the standardization and harmonization of existing cohort studies to obtain adequate statistical power with a sufficient sample size to analyze high-risk groups or rare cancer subtypes.
|
|
|
KEYWORD
|
|
|
Data pooling, Cohort studies, Follow-up studies
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|